Protein name:
Apoptosis-associated speck-like protein containing a CARD (mASC) ;
Alternative:
PYD and CARD domain-containing protein ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Forms complexes with other DAPIN domain-containing proteins. Interacts with CIAS1/PYPAF1 and PYDC1.
Function:
Promotes caspase-mediated apoptosis. This proapoptotic activity is mediated predominantly through the activation of caspase-9. May be a component of the inflammasome, a protein complex which also includes NALP2, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases.
Subcellular Location:
Cytoplasm
Upstream of caspase activation, a redistribution from the cytoplasm to the aggregates occurs. These appear as hollow, perinuclear spherical, ball-like structures.
Protein Attributes:
50:
MGRARDAILD | ALENLSGDEL | KKFKMKLLTV | QLREGYGRIP | RGALLQMDAI |
100:
DLTDKLVSYY | LESYGLELTM | TVLRDMGLQE | LAEQLQTTKE | ESGAVAAAAS |
150:
VPAQSTARTG | HFVDQHRQAL | IARVTEVDGV | LDALHGSVLT | EGQYQAVRAE |
193:
TTSQDKMRKL | FSFVPSWNLT | CKDSLLQALK | EIHPYLVMDL | EQS
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
Bovine
Polyclonal Antibody for Mouse mASC
Polyclonal Antibody for Mouse mASC
Polyclonal Antibody for Mouse mASC
Monoclonal Antibody for Mouse mASC
Monoclonal Antibody for Mouse mASC
Monoclonal Antibody for Mouse mASC
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
BALB/c .
tissue :
Thymus .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
FVB/N .
tissue :
Mammary tumor .
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[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6J .
tissue :
Pancreas .
tissue :
Tongue .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
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[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;DISRUPTION PHENOTYPE
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;DISRUPTION PHENOTYPE
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH CASP8